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  • Restoring Vision.
    Redefining the Future.
    Promise of Celliaz

    Advancing retinal regeneration
    through homeoprotein science

  • Millions live with
    retinal diseases.

    Current therapies slow progression.
    Celliaz aims to restore vision.

  • Unlocking Retinal
    Regeneration.

    Inspired by nature. Driven by science

  • Restoring Vision.
    Redefining
    the Future.
    With Celliaz

    Advancing retinal regeneration
    through homeoprotein science

  • Millions live with
    retinal diseases.

    Current therapies slow progression.
    Celliaz aims to restore vision.

  • Unlocking Retinal
    Regeneration.

    Inspired by nature. Driven by science

Why Retinal
Regeneration Matters

Retinal degenerative diseases continue to cause progressive
vision loss, affecting millions of patients worldwide.

Current treatments may slow disease progression,
but they cannot restore damaged retinal cells.

Key Facts
  • Progressive Vision Loss
  • Limited Treatment Options
  • High Unmet Medical Need

Why Retinal
Regeneration Matters

Retinal degenerative diseases continue to cause progressive vision loss, affecting millions of patients worldwide.

Current treatments may slow disease progression, but they cannot restore damaged retinal cells.

Key Facts
  • Progressive Vision Loss
  • Limited Treatment Options
  • High Unmet Medical Need

Millions of Patients

Retinal diseases affect millions
of people worldwide.

Unmet Medical Need

Current treatments have limitations
in restoring damaged retinal cells.

Future Opportunity

Retinal regeneration
offers new hope.

Millions of Patients

Retinal diseases affect millions
of people worldwide.

Unmet Medical Need

Current treatments have limitations
in restoring damaged retinal cells.

Future Opportunity

Retinal regeneration
Offers new hope.

Core Sicence

Understanding the Mechanism of Retinal Regeneration

Discover how Celliaz leverages PROX1 technology to unlock retinal regeneration
and create new possibilities for patients with retinal diseases.

Retinal Degeneration

Vision Loss Continues to Progress

Retinal diseases gradually
degenerate retinal cells,
leading to irreversible vision loss,
but have limited treatment options.

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>

Natural Regeneration
in Fish

A Regenerative Ability Human
Does Not Have

Unlike human, fish can naturally regenerate
retinal cells through Müller glial
reprogramming to retinal progenitor cells.

<
>

PROX1 Transfer

A Key Barrier to Retinal Regeneration

In the human retina, PROX1 accumulates
around Müller glia cells and suppresses
their regenerative activity after
transferring into Müller glia.

<
>

PROX1 Neutralization

Celliaz Therapeutic Approach

PROX1-neutralizing antibodies bind
PROX1 in the extracellular space and block
PROX1 transfer to Müller glia.

<
>

Retinal Regeneration

Restoring New Possibilities

In the absence of PROX1 transfer,
Müller glia can recover their regenerative potential
and support retinal repair.

<
>

Core Sicence

Understanding the Mechanism of
Retinal Regeneration

Discover how Celliaz leverages
PROX1 technology to unlock retinal regeneration and create new possibilities
for patients with retinal diseases.

Retinal Damage

Vision Loss Continues to Progress

Retinal diseases gradually damage retinal cells, leading to irreversible vision loss and limited treatment options.

<
>

Natural Regeneration
in Zebrafish

A Regenerative Ability Humans Do Not Have

Unlike humans, zebrafish can
naturally regenerate damaged retinal cells through Müller glia activation.

<
>

PROX1 Build-Up

A Key Barrier to Retinal Regeneration

In the human retina, PROX1 accumulates around Müller glia cells and suppresses their regenerative activity after transferring into Müller glia.

<
>

PROX1 Neutralization

Celliaz Therapeutic Approach

PROX1-neutralizing antibodies bind PROX1 in the extracellular space and block PRORX1 transfer to Müller glia.

<
>

Retinal Regeneration

Restoring New Possibilities

In the absence of PROX1 transfer,
Müller glia can recover their regenerative potential
and support retinal repair.

<
>

Visualizing Retinal Regeneration

Watch how Celliaz’s anti-PROX1 technology unlocks the regenerative potential of the retina.

  • Retinal Degeneration
  • PROX1 Transfer
  • PROX1 Neutralization
  • Müller Glial Reprogramming
  • Retinal Regeneration
Explore Our Science

Visualizing Retinal Regeneration

Watch how Celliaz’s anti-PROX1 technology unlocks the regenerative potential of the retina.

  • Retinal Damage
  • PROX1 Transfer
  • PROX1 Neutralization
  • Retinal Damage
  • Retinal Damage
Explore Our Science

Pipeline

Homeoprotein (HP) Targeting Therapeutics

Advancing innovative therapies through two complementary strategies.

Strategy 01

Remove Bad HPs

Neutralizing harmful HPs
that suppress tissue regeneration.

Core Asset : Anti-PROX1
Lead programs
  • CLZ001: Wet-AMD
  • CLZ002: Retinitis Pigmentosa
  • CLZ003: Dry-AMD
  • CLZ004: Alzheimer’s Disease

Strategy 02

Provide Good HPs

Delivering regenerative HPs
to restore tissue function and repair

Core Asset: Undisclosed
Lead programs
  • CLZ005: Muscle Regeneration
  • CLZ006: Hair Cell Regeneration
  • CLZ007: Corneal Regeneration

CLZ001 Wet-AMD

Lead Optimization

CLZ002 RP

Preclinical

CLZ003 Dry-AMD

Target Validation

CLZ004 Alzheimer’s Disease

Target Validation

7

Programs

2

Strategies

Multiple

Disease Areas
Explore Full Pipeline

Pipeline

Understanding the Mechanism of
Retinal Regeneration

Advancing innovative therapies through two complementary homeoprotein strategies.

Strategy 01

Remove Bad HPs

Neutralizing harmful homeoproteins that suppress tissue regeneration.

Core Asset : Anti-PROX1
Lead programs
  • CLZ001-Wet-AMD
  • CLZ002-Retinitis Pigmentosa
  • CLZ003-Dry-AMD
  • CLZ003-Alzheimer’s Disease

Strategy 02

Provide Good HPs

Delivering regenerative homeoproteins 
to restore tissue function and repair

Core Asset: Undisclosed
Lead programs
  • CLZ005: Muscle Regeneration
  • CLZ006: Hair Cell Regeneration
  • CLZ007: Corneal Regeneration

CLZ001 Wet-AMD

Lead Optimization

CLZ002 RP

Preclinical

CLZ003 Dry-AMD

Target Validation

CLZ004 Alzheimer's

Target Validation

7

Programs

2

Strategies

Multiple

Disease Areas
Explore Full Pipeline

Why Celiaz

Creating a New Therapeutic Paradigm for Degenerative Diseases

About Us

First-in-Class

Anti-PROX1 approach

Pioneering the Field

Leading the biotech industry by developing the world's first therapeutic platform that traps PROX1 proteins to unlock natural retinal regeneration.

Tissue Regeneration

Novel regenerative mechanism

Overcoming Boundaries

Breaking the limits of modern medicine by successfully repairing damaged retina, inspired by nature's perfect blueprint.

Broad Pipeline

7 active programs

Scalable Horizons

Expanding our therapeutic impact across 7 active programs, strategically targeting retinal diseases, Alzheimer’s, and tissue repair.

Strong
IP Portfolio

Patents and proprietary platform

Global Defensibility

Securing exclusive global rights and robust patent protection for our proprietary platforms, ensuring a strong competitive advantage.

Why Celiaz

Creating a New Paradigm for Retinal Regeneration

About Us

First-in-Class

Anti-PROX1 approach

Pioneering the Field

Leading the biotech industry by developing the world's first therapeutic platform that traps PROX1 proteins to unlock natural retinal regeneration.

Retinal Regeneration

Novel regenerative mechanism

Overcoming Boundaries

Breaking the limits of modern medicine by successfully restoring damaged photoreceptor networks, inspired by nature's perfect blueprint.

Broad Pipeline

7 active programs

Scalable Horizons

Expanding our therapeutic impact across 7 active programs, strategically targeting retinal diseases, Alzheimer’s, and tissue repair.

Strong
IP Portfolio

Patents and proprietary platform

Global Defensibility

Securing exclusive global rights and robust patent protection for our proprietary platforms, ensuring a strong competitive advantage.