Science
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Anti-PROX1 Platform Technology
Unlocking retinal regeneration by targeting PROX1,
the key suppressor of Müller glia reprogramming.
A Critical Barrier to
Regeneration
PROX1 is a transcription factor that suppresses
the regenerative potential of Müller glia following retinal injury.
In damaged mammalian retina, PROX1 is transferred to
Müller glia and prevents the natural reprogramming process
required for tissue repair.
Suppression
Suppresses Regenerative
Gene Expression
Müller Glia
Fails cellular reprogramming
Vision Loss
Limits functional recovery