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Retinal Regeneration Mechanism

Discover how Celliaz leverages Anti-PROX1 technology to unlock retinal
regeneration and create new possibilities for patients with retinal diseases.

Step 01

Retinal Damage

Vision Loss Continues to Progress

Retinal diseases gradually damage retinal cells,
leading to irreversible vision loss
and limited treatment options.

Step 02

Zebrafish Regeneration

A Regenerative Ability Humans
Do Not Have

Unlike humans, zebrafish can naturally regenerate damaged retinal cells
through Müller glia activation.

Step 03

PROX1 Transfer

A Key Barrier to Retinal egeneration

In the human retina, PROX1 accumulates around Müller glia cells and
suppresses their regenerative activity after transferring into Müller glia.

Step 04

PROX1 Neutralization

Celliaz Therapeutic Approach

PROX1-neutralizing antibodies bind PROX1 in the extracellular space and
block PROX1 transfer to Müller glia.

Step 05

Retinal Regeneration

Restoring New Possibilities

In the absence of PROX1 transfer, Müller glia can recover their
regenerative potential and support retinal repair.

Visualizing Retinal Regeneration

Watch how Celliaz’s anti-PROX1 technology unlocks the regenerative potential of the retina.

  • Retinal Damage
  • PROX1 Transfer
  • PROX1 Neutralization
  • Retinal Damage
  • Retinal Damage
Explore Anti-PROX1 Platform Technology