Retinal Regeneration Mechanism – Celliaz

Science

Science

Retinal Regeneration Mechanism

Discover how Celliaz leverages Anti-PROX1 technology to unlock retinal
regeneration and create new possibilities for patients with retinal diseases.

Step 01

Retinal Degeneration

Vision Loss Continues to Progress

Retinal diseases gradually
degenerate retinal cells,
leading to irreversible vision loss,
but have limited treatment options.

Step 02

Regeneration in Fish

A Regenerative Ability Human
Does Not Have

Unlike human, fish can naturally regenerate
retinal cells through Müller glial
reprogramming to retinal progenitor cells.

Step 03

PROX1 Transfer

A Key Barrier to Retinal Regeneration

In the human retina, PROX1 accumulates
around Müller glia cells and suppresses
their regenerative activity after transferring into Müller glia.

Step 04

PROX1 Neutralization

Celliaz Therapeutic Approach

PROX1-neutralizing antibodies bind
PROX1 in the extracellular space and block
PROX1 transfer to Müller glia.

Step 05

Retinal Regeneration

Restoring New Possibilities

In the absence of PROX1 transfer,
Müller glia can recover their regenerative
potential and initiate retinal repair.

Retinal Regeneration Mechanism

Discover how Celliaz leverages Anti-PROX1
technology to unlock retinal regeneration
and create new possibilities
for patients with retinal diseases.

Step 01

Retinal Degeneration

Vision Loss Continues to Progress

Retinal diseases gradually
degenerate retinal cells,
leading to irreversible vision loss,
but have limited treatment options.

Step 02

Regeneration in Fish

A Regenerative Ability Human
Does Not Have

Unlike human, fish can naturally regenerate retinal cells through Müller glial
reprogramming to retinal progenitor cells.

Step 03

PROX1 Transfer

A Key Barrier to Retinal Regeneration

In the human retina, PROX1 accumulates
around Müller glia cells and suppresses
their regenerative activity after transferring into Müller glia.

Step 04

PROX1 Neutralization

Celliaz Therapeutic Approach

PROX1-neutralizing antibodies bind
PROX1 in the extracellular space and block
PROX1 transfer to Müller glia.

Step 05

Retinal Regeneration

Restoring New Possibilities

In the absence of PROX1 transfer,
Müller glia can recover their regenerative
potential and initiate retinal repair.

Visualizing Retinal Regeneration

Watch how Celliaz’s anti-PROX1 technology unlocks the regenerative potential of the retina.

Visualizing Retinal Regeneration

Watch how Celliaz’s anti-PROX1 technology unlocks the regenerative potential of the retina.