Science
Science
Anti-PROX1 Retinal Regeneration Platform Technology
Unlocking retinal regeneration by targeting PROX1,
the key suppressor of Müller glia reprogramming.
Anti-PROX1 Retinal Regeneration Platform Technology
Unlocking retinal regeneration
by targeting PROX1, the key suppressor of Müller glia eprogramming.
A Critical Barrier to
Regeneration
PROX1 is a transcription factor that suppresses the regenerative potential of Müller glia following retinal injury.
In damaged mammalian retina, PROX1 is transferred to Müller glia and prevents the natural reprogramming process required for tissue repair.
Suppression
Suppresses Regenerative
Gene Expression
Müller Glia
Fails cellular reprogramming
Vision Loss
Limits functional recovery
Suppression
Suppresses Regenerative
Gene Expression
Müller Glia
Fails cellular reprogramming
Vision Loss
Limits functional recovery
One Platform,
Multiple Opportunities
Celliaz’s Anti-PROX1 regenerative platform is designed
to address multiple retinal diseases exhibiting a common
Müller glial PROX1 transfer.
Expanding the Future of Regenerative Medicine
From retinal regeneration to broader therapeutic opportunities.
Expanding the Future of Regenerative Medicine
From retinal regeneration to broader therapeutic opportunities.